DOES PRENATAL DIAGNOSIS AND EARLY POSTNATAL CARE OF POSTERIOR URETHRAL VALVES IMPROVE THE OUTCOME?

摘要

Introduction? Posterior urethral valves are severe congenital obstructive uropathies that could lead to renal failure and end stage renal disease despite the progresses in prenatal and postnatal diagnosis and management. Aim of the study: The aim of this paper is to study the relation between certain parameters and the long-term outcome of infants with and without a prenatal diagnosis of posterior urethral valves. Material and methods: Records of all children with posterior urethral valves treated in our center from January 2000 to December 2014 were retrospectively reviewed and statistically analyzed. Results? 31 patients were analyzed; no significant relations between the existence of the prenatal diagnosis of posterior urethral valves and the long time impairment of the renal function were revealed (χ2=3.02, p=0.08, 95%CI); a multivariable statistic analysis showed that high postnatal age at diagnosis and treatment was a risk factor predictable for poor outcome through renal function impairment (HR=5.139 → 95%CI: 2.01-6.18). Conclusion? Our data shows no relations between the existence of prenatal diagnosis of posterior urethral valves and their outcome, but a smaller age at the moment of treatment was observed in the prenatal group, with lower rates of renal function impairment.