A regioselective alkylation at the C-6 hydroxyl group of erythromycin A-oxime derivatives

摘要

Erythromycin A contains five hydroxyl groups. The regioselective alkylation at the C-6 hydroxyl group was achieved to an extent of more than 97 % when a 9-O-substituted erythromycin A-9-oxime was employed as the substrate.