A COMPARATIVE STUDY OF THERMODYNAMIC PROPERTIES OF STRUCTURALLY RELATED PHENOTHIAZINE DRUGS IN AQUEOUS SOLUTION

摘要

Association characteristics of amphiphilic phenothiazine drugs Fluphenazine and Trifluperazine dihydrochloride in water have been examined and their thermodynamic parameters have been calculated using conductometry. The electrical conductivity was measured as a function of concentration at various temperatures and cmc was calculated in the temperature range of 20-50°C. Thermodynamic parameters i.e. standard free energy of micellization, ΔG° , standard enthalpy of micellization, ΔH°m and standard entropy of micellization, ASm were calculated from cmc value using closed association model.