Different effects of prednisone treatment for 30 days and 90 days on bone metabolism in collagen-induced arthritis (CIA) rats

摘要

Background: Glucocorticoids (GCs) are often prescribed to treat RA for a long time, but there is still controversy in the administration of GCs, mainly because of the adverse reactions, such as osteoporosis. How to control the dosage and duration of GCs treatment is the problem we need to solve. The aim of this study was to investigate the different effects of prednisone treatment for 30 days and 90 days on bone metabolism in collagen-induced arthritis (CIA) rats and hope to provide a reasonably clinical application of glucocorticoids for the treatment of RA.