90-Day Oral Toxicity Study and a 5-Day Metabolism Study of DiisopropylMethylphosphonate (DIMP) in Mink

摘要

To reinvestigate the potential toxicity of diisopropyl methylphosphonate (DIMP)in mink (Mustela vison), a 90-day dose-feed study and a pharmacokinetic/metabolic study in mink and rats were conducted. Eighty 12-13 month-old brown Ranch Wild mink of each sex were randomized by body weight into eight dose groups of ten animals per sex. The animals were caged individually; food consumption and body weight were determined weekly. Blood samples were obtained before treatment began and at weeks 3, 7 and 13. All animals were examined at necropsy and microscopically. The target dose groups were 0, 50, 450, 2700, 5400 and 8000 ppm. The actual concentrations fed were between 97.6 and 133.5% of the target doses. Males and females in the 8000 ppm group consumed 20% and 24% less food than respective controls and overall mean body weight for both sexes was 18% less than the untreated control group.