Quercetin and epigallocatechin gallate in vitro induced changes in the membrane anisotropy of peripheral blood mononuclear cells from patients with inflammatory diseases

摘要

The aim of the study was to assess the?in vitro?effect of quercetin and epigallocatechin gallate on the membrane fluidity of mononuclear blood cells isolated from patients with an inflammatory profile (chronic hyperglycemia and rheumatoid arthritis). The measurements were performed via the evaluation of the fluorescence anisotropy for cells labeled with TMA-DPH. Chronic hyperglycemia does not impair the membrane anisotropy, as rheumatoid arthritis does. Quercetin had no significant effect on rheumatoid arthritis cells.? Epigallocatechin gallate had a stronger effect, improving the membrane fluidity characteristics for both hyperglycemia and rheumatoid arthritis patients.