Effect of α-lipoic acid combined with nerve growth factor on bone metabolism, oxidative stress and nerve conduction function after femoral fracture surgery

摘要

Objective: To discuss the effect of 毩-lipoic acid combined with nerve growth factor on bonemetabolism, oxidative stress and nerve conduction function after femoral fracture surgery.Methods: A total of 110 patients with femoral fracture who received surgical treatment inthe hospital between January 2015 and January 2017 were collected and divided into thecontrol group (n=55) and study group (n=55) by random number table. Control group receivedpostoperative nerve growth factor therapy, and study group received postoperative 毩-lipoicacid combined with nerve growth factor therapy. The differences in the contents of bonemetabolism and oxidative stress indexes as well as the levels of nerve conduction functionindexes were compared between the two groups before and after treatment. Results: Beforetreatment, the differences in the contents of bone metabolism and oxidative stress indexesas well as the levels of nerve conduction function indexes were not statistically significantbetween the two groups. After treatment, serum bone metabolism indexes BGP and PⅠNPcontents of study group were higher than those of control group while CTX-Ⅰ and TRAPcontents were lower than those of control group; serum oxidative stress indexes TAC, CAT andSOD contents of study group were higher than those of control group while MDA content waslower than that of control group; limb nerve conduction velocity SCV and MCV levels of studygroup were higher than those of control group. Conclusion: 毩-lipoic acid combined withnerve growth factor therapy after femoral fracture surgery can effectively balance osteoblast/osteoclast activity, reduce oxidative stress and improve limb nerve conduction velocity.