Effect of thyroid hormone on myocardial and cerebral ischemia reperfusion injury in valve replacement under cardiopulmonary bypass

摘要

Objective: To study the effect of thyroid hormone (euthyrox) on myocardial and cerebralischemia reperfusion injury in valve replacement under cardiopulmonary bypass. Methods:A total of 76 patients who received valve replacement under cardiopulmonary bypass in ourhospital between January 2013 and December 2016 were collected and divided into controlgroup (n=38) and observation group (n=38) according to random number table. Observationgroup took euthyrox orally 1 week before surgery, control group took vitamin C tablets orallyat the same point in time, and both therapies lasted for 1 week. Before taking medicine andafter cardiopulmonary bypass (before end of surgery), serum levels of myocardial enzymespectrum indexes and nerve injury indexes were compared between the two groups of patients.Results: Before taking medicine, differences in the serum levels of myocardial enzymespectrum indexes and nerve injury indexes were not statistically significant between the twogroups of patients. After cardiopulmonary bypass, serum myocardial enzyme spectrum indexescTnT, CK-MB, α-HBD and LDH levels in observation group were lower than those in controlgroup; serum nerve injury indexes NSE, S100B and GFAP levels were lower than those incontrol group while bFGF level was higher than that in control group. Conclusion: Euthyroxintervention in valve replacement under cardiopulmonary bypass can effectively reduce themyocardial and cerebral ischemia reperfusion injury.