The relationship between osteopontin expression and cell invasion as well as angiogenesis in preeclampsia placenta tissue

摘要

Objective: To study the relationship between osteopontin expression and cell invasion as wellas angiogenesis in preeclampsia placenta tissue. Methods: A total of 56 patients diagnosedwith preeclampsia in our hospital between June 2014 and March 2016 were selected aspreeclampsia group (PE group) and 80 normal subjects receiving antenatal examination andgiving birth during the same period were selected as control group. After labor, the placentatissue was collected, immunohistochemical staining kits were used to detect OPN expressionand enzyme-linked immunosorbent assay kits were used to determine cell invasion andangiogenesis molecule expression. Results: Positive OPN rate in placenta tissue of PE groupwas significantly lower than that of control group; cell invasion molecules LAMA4, uPA,Rho and ROCK as well as angiogenesis molecules VEGF, PIGF and AGF protein expressionin placenta tissue of PE group were significantly lower than those of control group, andcell invasion molecules LAMA4, uPA, Rho and ROCK as well as angiogenesis moleculesVEGF, PIGF and AGF protein expression in OPN-positive placenta tissue were significantlyhigher than those in OPN-negative placenta tissue. Conclusion: Lowly expressed OPNin preeclampsia placenta tissue will inhibit the expression of cell invasion molecules andangiogenesis molecules so as to inhibit sertoli cell invasion and the angiogenesis in placentatissue.