oligomeric compound or pharmaceutically acceptable salt thereof, pharmaceutical or veterinary composition, methods for inhibiting eif4e expression in a cell, tissue or organ, for decreasing proliferation of a cell in which eif4e is expressed, and for preventing or treating a condition or disease. methods for preventing or decreasing angiogenesis, and tumor growth in a patient, antisense oligonucleotide, pharmaceutical or veterinary composition, and use of an oligomeric compound or pharmaceutically acceptable salt thereof.

摘要

"OLIGOMIC COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT OF THIS PHARMACEUTICAL OR VETERINARY COMPOSITION, METHODS FOR INHIBITING E1F4E EXPRESSION IN A CELL, TISSUE OR ORGAN, TO DIMINATE ERE CULFERULATION OR CULIFERULATION1, METHODS TO PREVENT OR REDUCE ANGIOGENESIS, AND TUMOR GROWTH IN A PATIENT, ANTI-SENSE OLIGONUCLEOTIDE, PHARMACEUTICAL OR VETERINARY COMPOSITION, AND, USE OF AN UNDESIRABLE PHYMETHYETIC OR OLIGOMATIC COMPOUND. Oligomeric compounds, compositions and methods are provided to modulate eIF4E expression. Antisense compounds may be single or double stranded and are targeted to eIF4E-encoding nucleic acid. Methods of using these compounds for modulation of eIF4E expression and for the diagnosis and treatment of diseases and conditions associated with eIF4E expression are provided.