Correlation of anxiety with nerve injury and oxidative stress response in patients with acute cerebral infarction complicated by type 2 diabetes mellitus

摘要

Objective: To study the correlation of anxiety with nerve injury and oxidative stress response in patients with acute cerebral infarction complicated by type 2 diabetes mellitus. Methods: Patients with acute cerebral infarction complicated by type 2 diabetes mellitus that were treated in Jingzhou First People's Hospital between March 2015 and April 2017 were selected and divided into anxiety group and non-anxiety group according to HAMA score; the healthy subjects who received physical examination during the same period were selected as the control group. The serum contents of nerve injury markers, oxidative stress indexes and apoptosis indexes of three groups of subjects were measured. Results: Serum NSE, Glu, β-actin, NF155, sTM, MDA, ox-LDL, AOPP, sFas, sFasL and Caspase-3 levels of anxiety group and non-anxiety group were significantly higher than those of control group whereas GPx, SOD, Bcl-2 and Livin contents were lower than those of control group; serum NSE, Glu, β-actin, NF155, sTM, MDA, ox-LDL, AOPP, sFas, sFasL and Caspase-3 contents of anxiety group were significantly higher than those of non-anxiety group whereas GPx, SOD, Bcl-2 and Livin contents were lower than those of non-anxiety group. Conclusion: The anxiety in patients with acute cerebral infarction complicated by type 2 diabetes mellitus can aggravate the degree of nerve injury and oxidative stress response.