Design of PZT micropumps for biomedical applications: Glaucoma treatment

摘要

Micropumps have wide range of novel applications in medical field. The main purpose of this study was to find potential electro-mechanical design aspects of a micropump for Glaucoma disease treatment.? We suggested four new micropump designs, namely: single diaphragm micropumps at two different Piezoelectric Lead Zirconate Titanate (PZT-2) thicknesses, a bi-diaphragm micropump, and a peristaltic micropump. The driving voltage values in the simulations were 5V to 45V by 5V increments and the frequencies were 5Hz and 10Hz. Two dimensional analyses were done with COMSOL Multiphysics 4.3. We performed three different one-way ANOVAs and Multiple Comparison analyses. At different frequencies, there was a significant difference in flow rates (p=0.0465) and fluid pressure (p=0.0106) for each micropump design. At different driving voltages, displacement, fluid pressure and flow rate values were statistically different (p0.001) for all micropumps. The maximum flow rate obtained in peristaltic micropump which was 1.62×10 -27 ml/cycle. The maximum displacement of diaphragm occurred in bi-diaphragm micropump was 3.68×10 -3 mm which obtained at 45V and 5Hz. According to our result, peristaltic micropump design might be used for glaucoma treatment.