Letter to the editor: Temporary renal insufficiency associated with topical tacrolimus treatment of multilocal pyoderma gangrenosum

摘要

In renal transplant patients maintenance therapy with low dose tacrolimus and mycophenolate mofetil in combination is used to prevent renal injury and graft rejection.[1] On the other hand, calcineurin inhibitors can lead to chronic renal damage characterized by progressive and irreversible deterioration of renal function associated with interstitial fibrosis, tubular atrophy, arteriolar hyalinosis, and glomerulosclerosis in about 1% of patients.[2] Individual factors increase susceptibility to calcineurin-inhibitor related renal injury (CIRRI), such as expression of the metabolizing cytochrome P450 3A5 (CYP3A5) in kidneys although the pathogenesis of CIRRI is far from being fully understood.[3]