DEVELOPMENT, CHARACTERIZATION & STABILIZATION OF POORLY WATER SOLUBLE DRUGS UTILIZING SOLID DISPERSION TECHNIQUES BY USING Β - CYCLODEXTRIN

摘要

Telmisartan (TLM) is an angiotensin II receptor antagonist used in the treatment of hypertension. According to BCS (biopharmaceutical classification system) Telmisartan belongs to class II drug, and it is practically insoluble in water and it shows low dissolution profile and poor absorption. The present study is to improve the solubility of Telmisartan by forming complexation with β- CD by using four convenient methods viz physical mixing method, kneading method, and solvent evaporation fusion method at different molar ratios of 1:1, dissolution studies were carried out in pH 7.4 phosphate buffer. The cyclodextrin complexes formulated by employing 1:1 (drug: complexing agent) with kneading technique showed higher drug release.