Effect of ischemia-reperfusion on the post-rest inotropy of isolated perfused rat heart

摘要

This paper aims to study of the effects of ischemia-reperfusion on the post-rest inotropy and to characterize post-rest B1:B2 ratio as an index of intracellular Ca ²⁺ overload. When the rest interval between the cardiac beats is increased, the magnitude of the post-rest beats is increased. First beat (B1) is maximally potentiated with exponental decline of the second (B2) and subsequent beats, thereby establishing a normal B1:B2 ratio of post- rest inotropy of the cardiac muscle. The rest potentiation of B1 and subsequent decay in the magnitude B2 is thought to develop from the time-dependent changes in the Ca ²⁺ -uptake and release from the sarcoplasmic reticulum (SR). Ca ²⁺ -kinetics of SR can be modulated by a variety of interventions which produce Ca ²⁺ loading of the SR.