Patterns and Trends of Rifampicin-Resistance Mycobacteriumtuberculosis and Associated Factors among Presumptive TuberculosisPatients at Debre Berhan Referral Hospital

摘要

In Ethiopia, evidence on rifampicin-resistant Mycobacterium tuberculosis is rare. Therefore, this study aims to assess pattern of Rifampicin-resistance Mycobacterium tuberculosis (MTB) and associated factors among presumptive tuberculosis patients. A retrospective cross-sectional study design was conducted among presumptive tuberculosis (TB) cases at Debre Berhan referral hospital. Data were collected from registration books using checklist. Data were entered to Epi-data and analyzed using SPSS version 21. Results were summarized using regression statistics and presented with frequency tables and figures. P-value less than or equal to 0.05 was taken as statistically significant. Of a total of 3689 (male=51%, female=49%) presumptive cases screened at Debre Berhan referral hospital Laboratory with gene-x-pert; 34.4% and 65.6% were from urban and rural respectively, with mean age of 33.8 year. 483 (13%) cases were found to be TB positive, of which 25 (5.2%) were with rifampicin resistance. Family member 2 3, contact history with TB suspect, previous treatment history and age group 16-30 years were found in 80%, 64%, 28% and 44% of rifampicin resistance cases, respectively. Sero-status of rifampicin resistance cases were statistically significant association (p=0.013, AOR=2.97, Cl=1.059-17). The overall prevalence of Mycobacterium tuberculosis and Rifampicin resistance Mycobacterium tuberculosis was high. Most of the affected study subjects were also productive age group (16-30 years). Therefore, wide range of awareness creation is mandatory. The availability of gene-x-pert should be scaled up and avail at large for early diagnosis and treatment.