Combination immunotherapy with anti-CTLA-4 and interleukin-2 redirects regulatory T cells into tumor-draining lymph nodes and expands anti-tumor CD8+ T cells in the tumor microenvironment

Joseph Broucek; Tasha Hughes; Erica Huelsmann; Eugene Lusciks; Graham Hill; Janet Zayas; Joseph Poshepny; Carl Ruby; Frederick Kohlhapp; Andrew Zloza; Howard Kaufman

首页> 外文期刊>Journal for ImmunoTherapy of Cancer >Combination immunotherapy with anti-CTLA-4 and interleukin-2 redirects regulatory T cells into tumor-draining lymph nodes and expands anti-tumor CD8+ T cells in the tumor microenvironment

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Combination immunotherapy with anti-CTLA-4 and interleukin-2 redirects regulatory T cells into tumor-draining lymph nodes and expands anti-tumor CD8+ T cells in the tumor microenvironment

机译：结合抗CTLA-4和白介素2的免疫疗法可将调节性T细胞重定向至引流肿瘤的淋巴结，并在肿瘤微环境中扩增抗肿瘤CD8 + T细胞

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来源
《Journal for ImmunoTherapy of Cancer》 |2014年第s3期|共页
作者
Joseph Broucek; Tasha Hughes; Erica Huelsmann; Eugene Lusciks; Graham Hill; Janet Zayas; Joseph Poshepny; Carl Ruby; Frederick Kohlhapp; Andrew Zloza; Howard Kaufman;
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中图分类肿瘤学;
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1. Cryo-ablation improves anti-tumor immunity through recovering tumor educated dendritic cells in tumor-draining lymph nodes [J] . Xiao-Zheng He, Qi-Fu Wang, Shuai Han, Drug Design, Development and Therapy . 2015,第5期

机译：冷冻消融可通过在引流肿瘤的淋巴结中恢复受过肿瘤教育的树突状细胞来提高抗肿瘤免疫力
2. Different cytokine profiles released by CD4+ and CD8+ tumor-draining lymph node cells involved in mediating tumor regression. [J] . A Aruga, A E Chang, E Aruga, Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society . 1997,第4期

机译：CD4 +和CD8 +引流肿瘤的淋巴结细胞释放的不同细胞因子谱参与介导肿瘤消退。
3. pistribution of Th17 cells and FoxP3(+) regulatory T cells in tumor-infiltrating lymphocytes, tumor-draining lymph nodes and peripheral blood lymphocytes in patients with gastric cancer [J] . Takanori Maruyama, Koji Kono, Yoshiki Mizukami, Cancer science. . 2010,第9期

机译：胃癌患者肿瘤浸润淋巴细胞，引流淋巴结和外周血淋巴细胞中Th17细胞和FoxP3（+）调节性T细胞的分布
4. TARGETING THE TUMOR-DRAINING LYMPH NODE WITH ADJUVANT NANOPARTICLES FOR CANCER IMMUNOTHERAPY [C] . Susan N. Thomas ASME bioengineering conference . 2014

机译：用辅助纳米颗粒靶向排毒淋巴结进行癌症免疫治疗
5. The Immune Checkpoint B7x Promotes the Induction of Regulatory T Cells in the Tumor Microenvironment and Mediates Resistance to Immunotherapy [D] . John, Peter. 2022

机译：免疫检查点B7X促进肿瘤微环境中调节性T细胞的诱导，并介导对免疫疗法的抗性
6. Combination immunotherapy with anti-CTLA-4 and interleukin-2 redirects regulatory T cells into tumor-draining lymph nodes and expands anti-tumor CD8+ T cells in the tumor microenvironment [O] . Joseph Broucek, Tasha Hughes, Erica Huelsmann, 2014

机译：结合抗CTLA-4和白介素2的免疫疗法可将调节性T细胞重定向至引流肿瘤的淋巴结并在肿瘤微环境中扩增抗肿瘤CD8 + T细胞
7. Combination immunotherapy with anti-CTLA-4 and interleukin-2 redirects regulatory T cells into tumor-draining lymph nodes and expands anti-tumor CD8+ T cells in the tumor microenvironment [O] . 2014

机译：结合抗CTLA-4和白介素2的免疫疗法可将调节性T细胞重定向至引流肿瘤的淋巴结，并在肿瘤微环境中扩增抗肿瘤CD8 + T细胞

Combination immunotherapy with anti-CTLA-4 and interleukin-2 redirects regulatory T cells into tumor-draining lymph nodes and expands anti-tumor CD8+ T cells in the tumor microenvironment

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