A comparative evaluation of Clonidine, Fentanyl and Combination of both as Adjucants to Ropivacaine in Epidural block for Perineral and lower limb Surgeries

摘要

The current study evaluated the effect of fentanyl and clonidine as adjuvants with Ropivacaine in epidural block In our study, 120 patients were randomly allocated to one of the four study groups i.e. Group I (R)-20 ML of .75% of Ropivacaine + 2ml NS; Group II (RC)-20 ML of .75% of Ropivacaine + 2ml of NS containing 75u of Clonidine, Group III (RF) -20 ML of .75% of Ropivacaine + 2ml of NS containing 75u of Fentanyl; Group IV (RCF)- 20 ML of .75% of Ropivacaine + 2ml of Saline containing 37.5u Clonidine + 37.5u Fentanyl.. After observing various sensory and motor blockade characteristics in the four groups, , it was found that addition of Clonidine and Fentanyl hastened the onset of sensory and motor block and also provided longer, complete and effective analgesia in adjuvant groups than control group. A significant incidence of side effects was noted in RF and RC groups. A reduction in doses of Clonidine and Fentanyl in RCF group did not make any significant difference in block characteristics but there was significant decrease in the incidence of side effects.