Comparison of the Effects of Benzodiazepine and Nonbenzodiazepine Anxiolytics on Mouse-Killing Behavior in Rats

摘要

References(16) Cited-By(3) The present study investigated the effects of nonbenzodiazepine anxiolytics on mouse-killing behavior in rats, compared with the effects of benzodiazepine anxiolytics. Mouse-killing behavior was induced by bilateral olfactory bulbectomy. The following drugs were administered 1ntraperitonea Ily: chlord 1azepoxide, diazepam, ethyl loflazepate, fludiazepam, zopiclone, suriclone, and CL 218, 872. Among these drugs, suriclone (ED50=1.3 mg/kg) and fludiazepam (ED50=5.9 mg/kg) showed potent suppressive effects. Diazepam, ethyl loflazepate, and CL 218, 872 showed only weak actions on mouse-killing behavior.