Ocotillol-type derivatives (II) synthesis and protective effects on cultured anoxia/reoxygen injury myocardiocytes

摘要

The ocotillol-type derivatives (3β, 12β)-12, 25-dihydroxy-20S, 24R-epoxy-dammar-24-en-3-yl-2-O-β-D-glucopyranosyl-β-D-glucopyranoside and (3β, 6α, 12β)-3, 12, 25- trihydroxy- 20S, 24R- epoxy- dammar-24-en-6-yl-2-O-[6-deoxy-α-L-mannopyranosyl]-β-D-glucopyranoside (3a and b) had been designed and synthesized from 20 (S)-Rg3 and 20 (S)-Rg2 which structures were confirmed byelectrospray ionization mass spectrometry(ESI-MS),Hydrogen-Nuclear magnetic resonance(1H-NMR)andcarbon-Nuclear magnetic resonance(13C-NMR). 20(S)-Rg3, 20(S)-Rg2, 3a and b were evaluatedIn vitrofor its protective effect on cultured myocardiocytes with anoxia /reoxygen injury. The pharmaceutical data appeared that these four compounds had protective effect and 3a showed the most potent bioactivity among them.