The Protective Effect of Vitamin C on Irradiated Testes of Albino Rat

摘要

The increased exposure to radiation in medicine or industries increases the hazards of radiation on various organs of the human body. The aim of this work was to evaluate the protective effect of anti oxidant (vitamin C) against the effect of radiation on rat testes. Thirty adult albino rats were divided into three groups, each contained ten rats .The first group (G.1) was exposed to 415 r (G.1') or 622 r (G.1") using x-ray source for one minute per day for one week. The second group (G.2) was exposed to 415 r (G.2') or 622 r (G.2") using x- ray source for one minute per day for one week, in addition to vitamin C equivalent to 86.9 mg./liter orally for the two sub groups for the same period . The third group (G.3) was a control group. The examined testes of G.1 showed damaged germinal epithelium with remaining some layers of spermatogonia. There was no affection of spermatocytes, mature sperms, Sertoli cells and Leydig cells, the lumen contained little sperms and debris of germ cells (G.1') .While for (G.1") there was marked damage of the seminiferous tubules with irregular outline, destruction of spermatogonia, spermatocytes and spermatids with pyknotic type of nuclear degeneration and the lumen was devoid of mature sperms. The examined testes of the (G.2) showed evidence of almost complete recovery for G .2' and marked recovery for G.2" It is concluded that anti oxidants were essential to patients exposed to x-ray , to guard against its hazards