Prevalence and determinants of left ventricular geometric abnormalities in hypertensive patients: A study based on the updated classification system of left ventricular geometry

摘要

Abstract Objective This study was to determine whether different risk factors were associated with different type of left ventricular (LV) geometric abnormalities. Methods This retrospective analysis included 2290 hypertensive participants without other cardiovascular disease, valve disease and with ejection fraction ≥50%. The type of {LV} geometric abnormality was defined on the basis of the new classification system. Results {LV} geometric abnormalities were detected in 1479 subjects (64.6%), wherein concentric {LV} remodeling is the most common {LV} geometric abnormality (40.3%). Large waist circumference (WC) and neck circumference (NC) were positively associated with concentric {LV} remodeling, whereas body mass index (BMI) [odds ratio (OR) 0.89, 95% {CI} 0.85～0.92, P ＜ 0.001] and systolic blood pressure (SBP) (OR 0.99, 95% {CI} 0.98～0.99, P = 0.018) were inversely associated with concentric abnormalities. {SBP} and age were positively associated with eccentric dilated LVH, while male was inversely associated with eccentric dilated left ventricular hypertrophy (LVH). Age was the strongest risk factor for eccentric dilated {LVH} (OR 1.05, 95% {CI} 1.03～1.07, P ＜ 0.001). Age, NC, SBP, hyperuricemia, and alcohol use were positively associated with concentric LVH, whereas {BMI} (OR 0.95, 95% {CI} 0.90～0.99, P = 0.033) and male (OR 0.12, 95% {CI} 0.07～0.18, P ＜ 0.001) were negatively associated with concentric LVH. Conclusion The prevalence of hypertensive {LV} geometric abnormality in rural area of Southern China was obvious higher. Compared with eccentric {LV} geometric abnormalities, there were more risk factors, including large {WC} and NC, age, NC, SBP, hyperuricemia, alcohol use, {BMI} and gender, which were associated with concentric {LV} geometric abnormalities.