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The impact of pre and perinatal lifestyle factors on child long term health and social outcomes: a systematic review

机译:产前和围产期生活方式因素对儿童长期健康和社会后果的影响:系统评价

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To understand the full extent of the impact of a trial, it is important to consider the long-term consequences of outcomes beyond the trial follow-up period, especially for early year’s interventions. A systematic review of the literature associated with the long-term consequences of four key outcomes from the Building Blocks trial, specifically, low birth weight, smoking during pregnancy, interval to subsequent pregnancy and A&E attendance or inpatient admission was conducted. These factors were guided by the funders, the Department of Health, as being of particular interest in the UK context. Relevant studies were identified from a number of sources including large databases, reference checking and citation searching. The search yielded 3665 papers, 43 of which were considered appropriate for inclusion. Of these, 29 were relating to smoking during pregnancy, 13 to low birth weight, 0 to A&E attendances during early childhood and 1 to short (
机译:为了全面了解试验的影响,重要的是要考虑试验随访期之后的结果的长期后果,尤其是对于早期干预而言。对与Building Blocks试验的四个关键结果的长期后果相关的文献进行了系统的回顾,特别是低出生体重,怀孕期间吸烟,间隔至随后的怀孕和急诊就诊或住院。这些因素在卫生部的资助者的指导下进行,因为这在英国尤为重要。从包括大型数据库,参考文献检查和引文检索在内的许多资源中确定了相关研究。搜索产生3665篇论文,其中43篇被认为适合纳入。其中,29例与怀孕期间吸烟有关,13例与低出生体重有关,0例与儿童早期的急症就诊相关,1例与随后的怀孕间隔短(<2年)。人们发现孕妇在怀孕期间吸烟与吸烟对儿童健康,教育程度以及以后生活中发生问题行为和犯罪活动的可能性之间存在着联系。出生时体重过轻还会影响儿童的长期健康和认知能力。上次出生后两年内的后续妊娠与早产和新生儿死亡的可能性增加相关。对于短暂的第二次怀孕间隔以及对儿童急症和门诊的影响,仅发现了极少的证据。鉴于英国卫生部已将这些结果确定为英国利益特别感兴趣,因此建议对这些领域的研究进行投资,以更清晰地了解短期和长期后果。

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