Sporadic Creutzfeldt-Jakob Disease Presenting as Corticobasal Syndrome: A Rare Case

摘要

Dear Editor,A 56-year-old male was admitted to our neurosurgery polyclinic with clumsiness and weakness of his left arm. Diffusion-weighted magnetic resonance imaging (MRI) showed an infarction, and he was discharged with low-molecular-weight heparin. It was learned that he had new symptoms including desperation, reticence, slowness in motions, imbalance, being withdrawn, and forgetfulness, which initiated one month after his discharge.Six months later, the patient was admitted to the neurology polyclinic because of worsening in his quality of life. His neurologic examination showed myoclonus, dysarthria, bilateral upper limb apraxia, alien hand phenomenon, bilateral rigidity, and bradykinesia predominantly affecting the left side. His mood was depressive. His mini mental state examination (MMSE) score was 16/30. An investigation for autoimmune markers and a paraneoplastic panel resulted negatively. An ophthalmologic examination was normal. Cranial MRI showed mild cortical atrophy. The patient was considered as having probable corticobasal syndrome, and L-dopa was initiated with a dose of 375 mg/day.