Some bioactive organotin(IV) derivatives with 3,4-dichlorophenylacetic acid: synthesis, spectroscopic properties, and X-ray structure of [Sn_4(C_4H_9)_8(OOCCH_2C_6H_3Cl_2)_4O_2]

摘要

Some bioactive organotin(IV) derivatives of3,4-dichlorophenylacetic acid (HL) were synthesized by reacting theligand acid with various di- or tri-organotin compounds (in suitablemole ratios) in the presence of triethylamine. The structuralinvestigation was carried out via multinuclear (^1H, ^{13}C, and^{119}Sn) NMR, IR spectroscopy, and X-ray crystallography. Thecrystal structure of 4 comprises a central Sn_2O_2 core with O atomsbonded to 2 dibutylbis(3,4-dichlorophenylacetato)tin(IV) units. Allthe Sn atoms of 4 are essentially 5-coordinated in distortedtrigonal-bipyramidal geometry. Some of the compounds exhibitedsignificant antibacterial and antifungal activity.