Some bioactive organotin(IV) derivatives with 3,4-dichlorophenylacetic acid: synthesis, spectroscopic properties, and X-ray structure of [Sn4(C4H9)8(OOCCH2C6H3Cl2)4O2]

摘要

Some bioactive organotin(IV) derivatives of 3,4-dichlorophenylacetic acid (HL) were synthesized by reacting the ligand acid with various di-or tri-organotin compounds (in suitable mole ratios) in the presence of triethylamine. The structural investigation was carried out via multinuclear (~1H, ~(13)C, and ~(119)Sn) NMR, IR spectroscopy, and X-ray crystallography. The crystal structure of 4 comprises a central Sn2 O2 core with O atoms bonded to 2 dibutylbis(3,4-dichlorophenylacetato)tin(IV) units. All the Sn atoms of 4 are essentially 5-coordinated in distorted trigonal-bipyramidal geometry. Some of the compounds exhibited significant antibacterial and antifungal activity.