Synthesis of some new biheterocyclic triazole derivatives and evaluation of their antimicrobial activity

摘要

2-{3-(4-Substitutedbenzyl)-4-[2-(1H-indol-3-yl)ethyl]-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}-N'-(aryl-methylene)acetohydrazides (5a-g),4-amino-2-{-(4-substitutedbenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}-N'-(arylmethylene)acetohydrazides (6a,b), and 4-[2-(1H-indol-3-yl)ethyl]-5-(4-substitutedbenzyl)-2-{5-(phenylamino)-1,3,4-thiadiazol-2-yl]methyl}-2,4-dihydro-3H-1,2,4-triazol-3-ones (8a,b) weresynthesized starting from 4-alkyl-5-(4-substitutedbenzyl)-2,4-dihydro-3H-1,2,4-triazol-3-ones (2a-c) by several steps and their structureswere well characterized by elemental analyses, IR, ^1H-NMR,^{13}C-NMR, and mass spectral studies. They were also screened fortheir microbial activities. The obtained antimicrobial activityresults revealed that 12 among the 24 compounds tested displayedvariable growth inhibition effects on the tested gram-positive andgram-negative bacterial strains. None of the compounds showedantifungal activity against yeast-like fungi.