Real-Time Monitoring of Fibrinogen Cross-Linking on Model Biomaterial Surfaces with Quartz Crystal Microbalance

摘要

A quartz crystal microbalance was used for real-time monitoring of fibrinogen cross-linking on three modelbiomaterial surfaces. Fibrinogen adsorbs slowly and forms a less rigid multi-layer on hydrophobic surfaces, while it adsorbsquickly, forming a single mono-layer on hydrophilic surfaces. The extent of fibrinogen cross-linking is greater onhydrophobic surfaces. Fibrinogen cross-linking can also rigidify the relatively soft coatings of poly(methyl methacrylate)and dodecanethiol self-assembled monolayer.