Real-time characterization of biomaterial compatibility using Quartz Crystal Microbalance with Dissipation monitoring (QCM-D)

摘要

When designing artificial biomaterials to be used in the field of orthopedic implantology or stents it is of crucial interest to ensure a low level of immune response and avoiding infections caused by these materials. The Quartz Crystal Microbalance with Dissipation monitoring technique (QCM-D) enables monitoring of the adsorption at a solid-liquid interface in real-time. QCM-D can successfully be used to provide information on molecular adsorption processes with various surfaces via the quantification of parameters such as mass, thickness, viscosity and shear modulus of the sensor surface adhering film. Here, we present two studies where the technique has been used to obtain information on biocompatibility of artificial biomaterials.