Protein Aggregation in the Cell Nucleus: Structure, Function and Topology

摘要

The nucleus represents a cellular control unit that regulates all events concerning the storage and processing ofDNA and RNA. It is organized by highly crowded, dynamic assemblies of proteins and nucleic acids in molecularmachines, ribonucleoprotein complexes, clusters of ongoing nuclear processes, nuclear bodies, and chromatin. Thisreview discusses the occurrence of nuclear protein aggregation with special emphasis on the functional architecture of thenucleus, and quality control by the ubiquitin-proteasome system.