Genetic Variation in NR1H4 Encoding the Bile Acid Receptor FXR Determines Fasting Glucose and Free Fatty Acid Levels in Humans

Martin Heni; Robert Wagner; Caroline Ketterer; Anja B?hm; Katarzyna Linder; Fausto Machicao; Jürgen Machann; Fritz Schick; Anita M. Hennige; Norbert Stefan; Hans-Ulrich H?ring; Andreas Fritsche; Harald Staiger

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Genetic Variation in NR1H4 Encoding the Bile Acid Receptor FXR Determines Fasting Glucose and Free Fatty Acid Levels in Humans

机译：编码胆汁酸受体FXR的NR1H4的遗传变异确定人的空腹血糖和游离脂肪酸水平

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Context:Bile acid signaling via farnesoid X receptor (FXR) regulates glucose and lipid levels, fat mass, and hepatic steatosis in animal models.

机译：背景：通过法尼醇X受体（FXR）发出的胆汁酸信号调节动物模型中的葡萄糖和脂质水平，脂肪量和肝脂肪变性。

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《The journal of clinical endocrinology and metabolism》 |2013年第7期|共6页
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Martin Heni; Robert Wagner; Caroline Ketterer; Anja B?hm; Katarzyna Linder; Fausto Machicao; Jürgen Machann; Fritz Schick; Anita M. Hennige; Norbert Stefan; Hans-Ulrich H?ring; Andreas Fritsche; Harald Staiger;
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1. Association of genetic variation in the NR1H4 gene, encoding the nuclear bile acid receptor FXR, with inflammatory bowel disease [J] . Ragam Attinkara, Jessica Mwinyi, Kaspar Truninger, BMC research notes . 2012,第1期

机译：编码核胆汁酸受体FXR的NR1H4基因的遗传变异与炎症性肠病的关联
2. Cholesterol feeding prevents hepatic accumulation of bile acids in cholic acid-fed farnesoid X receptor (FXR)-null mice: FXR-independent suppression of intestinal bile acid absorption. [J] . Miyata M, Matsuda Y, Nomoto M, Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2009,第2期

机译：胆固醇喂养可防止胆汁酸喂养的法尼醇X受体（FXR）无效小鼠肝内胆汁酸的积累：FXR独立的肠胆酸吸收抑制。
3. Influence of hypothalamically induced restlessness under fasted and fed conditions on plasma levels of glucose, free fatty acids and total cholesterol [J] . Kyoji Kojima, Souher Mohamed, Yasuaki Fujimaru, Stress and health: journal of the International Society for the Investigation of Stress . 2001,第2期

机译：空腹和进食条件下下丘脑诱发的躁动对血浆葡萄糖，游离脂肪酸和总胆固醇水平的影响
4. Regulation of bile acid homeostasis by the nuclear bile acid receptor FXR and fibroblast growth factor 15 [C] . S. R. HOLMSTROM, M. CHOI, T. INAGAKI, International Bile Acid Meeting . 2007

机译：核胆汁酸受体FXR和成纤维细胞生长因子15调节胆汁酸性稳态
5. The Short Chain Fatty Acid Receptor, Free Fatty Acid-2 Receptor (FFA2), Contributes to Gestational Glucose Homeostasis through a Novel Relationship Between Pancreatic Beta Cells, Short Chain Fatty Acids and the Gut Microbiota. [D] . Fuller, Miles Henry. 2016

机译：短链脂肪酸受体，游离脂肪酸2受体（FFA2）通过胰腺β细胞，短链脂肪酸和肠道菌群之间的新关系，有助于妊娠期葡萄糖体内稳态。
6. Association of genetic variation in the NR1H4 gene encoding the nuclear bile acid receptor FXR with inflammatory bowel disease [O] . Ragam Attinkara, Jessica Mwinyi, Kaspar Truninger, 2012

机译：编码核胆汁酸受体FXR的NR1H4基因遗传变异与炎症性肠病的关联
7. Genetic Variation in NR1H4 Encoding the Bile Acid Receptor FXR Determines Fasting Glucose and Free Fatty Acid Levels in Humans [O] . Heni, Martin, Wagner, Róbert, Ketterer, Caroline, 2013

机译：编码胆汁酸受体FXR的NR1H4的遗传变异确定人的空腹血糖和游离脂肪酸水平

Genetic Variation in NR1H4 Encoding the Bile Acid Receptor FXR Determines Fasting Glucose and Free Fatty Acid Levels in Humans

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