Isolated human monoclonal antibody that specifically binds to human glucagon receptor or Antigen binding Fragment of the same; Nucleic Acid Molecule that encodes; expression vector; production method; Pharmaceutical composition containing same and their use for treating a disease or condition Tion associated with high levels of glucose or ketones in the blood.

摘要

The present invention provides antibodies that bind to the human glucagon receptor, designated GCGR and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human GCGR. The antibodies of the invention are useful for lowering blood glucose levels and blood ketone levels and are also useful for the treatment of diseases and disorders associated with one or more GCGR biological activities, including the treatment of diabetes, diabetic ketoacidosis and long-term complications associated with diabetes, or other metabolic disorders characterized in part by elevated blood glucose levels.