首页> 外文期刊>The journal of clinical endocrinology and metabolism >NOS3 Glu298Asp Polymorphism Interacts with Virgin Olive Oil Phenols to Determine the Postprandial Endothelial Function in Patients with the Metabolic Syndrome
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NOS3 Glu298Asp Polymorphism Interacts with Virgin Olive Oil Phenols to Determine the Postprandial Endothelial Function in Patients with the Metabolic Syndrome

机译:NOS3 Glu298Asp多态性与初榨橄榄油酚相互作用,以确定代谢综合征患者的餐后内皮功能

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Background:Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene ( NOS3 ) has been characterized as a risk factor of hypertension and coronary artery disease. Previous studies suggest that the higher risk observed in T allele carriers is due to endothelial dysfunction associated with a lower eNOS activity and that acute consumption of phenol-rich olive oil ameliorates postprandial endothelial dysfunction by reducing oxidative stress and increasing nitric oxide bioavailability. Nevertheless, how these facts may interact in a population with altered endothelial function such as metabolic syndrome patients remains unknown.
机译:背景:内皮型一氧化氮合酶(eNOS)基因(NOS3)的Glu298Asp多态性已被表征为高血压和冠心病的危险因素。先前的研究表明,在T等位基因携带者中观察到的较高风险归因于内皮功能障碍,而eNOS活性较低,而富含苯酚的橄榄油的急性食用可通过减少氧化应激和增加一氧化氮的生物利用度来改善餐后内皮功能障碍。然而,这些事实如何在具有内皮功能改变的人群(如代谢综合征患者)中如何相互作用尚不清楚。

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