A retrospective study of children with neuroblastoma at our tertiary centre with varied pattern of presentation, protocol based management and outcome in these kids

摘要

:Neuroblastoma is a neuroendocrine tumor arising from theneural crest of the sympathetic nervous system.It is the most commonextracranial solid tumor of childhood, which is often localized in theretroperitoneal space, mainly in the adrenal glands, paravertebral retro-peritoneal space, at rare in the posterior mediastinum,in neck,presacralarea.It has a diverse clinical presentation and course depending on thetumour biology.First symptoms of neuroblastoma are nonspecific,mimicvarious diseases.Clinical manifestations depend on the localization of thetumor,stage presence and location of metastases.Unique features of thesetumours are the early age of onset,the high frequency of metastatic diseaseat diagnosis and the tendency for spontaneous regression of tumours ininfancy.Most malignant tumours have amplification of the MYCN onco-gene which is usually associated with poor outcome,even in localizeddisease.