Comparative evaluation of antioxidant drug influence on a radio therapy efficiency and oxidative status in mice

摘要

The. aim. of. the. study. is. a. comparative. analysis. of. the. effect. of. melatonin. (Melaxen). and. 3?hydroxypyridine. (Mexidol). on.antitumor. and. antimetastatic. influence. of. chemoradiotherapy. and. oxidative. status. at. mice. with. Lewis. lung. carcinoma.. Material. ?a.Experiments. have.been. organized. on. 95. mice.of. C57Bl/6. line. and. of.20¨C22. g. in.weight..Cyclophosphan. has.been. abdominally. administered.two. times. in. a. dosage. of. 60. mg/kg. within. the. interval. of. 120. hours. ?a. 20?30. min. before. radiotherapy.. It. has. been. located. on. the. area. of.initia l. tumor. in. a. dosage. of. 2. g. at. the. same. time. as. cyclophosphan. injection.. Melaxen. and. Mexidol. have. been. intramuscularly. injecting. in.the.dosage.of. 45.and. 50.mg/. kg.for.14. days..Antitumor.and. antimetastatic. effect.of. the. applied. therapy.and.changes. in. the. oxidative.status.of. the. animals. have. been. estimated.. Results. ?a. Melaxen. and. Mexidol. do. not. decrease. antitumour. and. antimetastatic. effects. of.radiotherapy. and. prevent. the. activation. of. free. radical. processes. at. animals. with. tumors.. Mexidol. was. more. effective. than. Melaxen. in.correction. of. superoxide. dismutase. activity. in. liver.. The. drugs. under. the.study. do. not. decrease. radiotherapy?induced. lipid. peroxidation. in.the.initial.tumor.. Conclusion. ?a. Melaxen. and. Mexidol.do. not. decrease. the. radio. therapy.efficiency. and.oxidative. status. at. mice.with. tumor.(on. the. background. of. antitumor. treatment