Cell membrane alteration by weak alternating electric field at low frequency

摘要

The aim is to estimate the influence of sinusoidal (ac) field in combinationwith the cytostatic drug gemcitabine on the therapeutic effect of malignant cells.Electrotreatment is cell line dependent. There is threshold frequency window (1Hz) thatis the most suitable for drug delivery. Hematopoietic cells are more sensitive to theelectrotreatment as compared with human lymphocytes from healthy donors.