Effect of ammonium glycyrrhizinate on haloperidol- and reserpine- induced neurobehavioral alterations in experimental paradigms

摘要

The present work was aimed to assess the effect of ammonium glycyrrhizinate, AG (50, 100, and 150?mg/kg, i.p.) on haloperidol induced catalepsy in mice; reserpine induced orofacial dyskinesia in rats; and reserpine antagonism in mice. Additionally the effect of AG on lipid peroxidation (LP) in cataleptic mice brain and monoamine oxidase-B (MAO-B) levels in normal mice brain was assessed. Administration of AG 100 and 150?mg/kg showed significant reduction in the duration of cataleptic behavior at 60 to 180?min and dose dependent decrease in LP induced by haloperidol. AG showed significant decrease in frequency of vacuous chewing movements at 150?mg/kg and frequency of tongue protrusion at 100 and 150?mg/kg in reserpine induced orofacial dyskinesia test. AG showed significant increase in frequency of horizontal movement and rearing behavior at 150?mg/kg and increase in grooming behavior at 100 and 150?mg/kg in reserpine antagonism test. AG showed dose dependent inhibition of MAO-B in the normal mice brain. These results suggested that AG prevented the haloperidol- and reserpine- induced neurobehavioral alterations possibly by acting as free radical scavenger or inhibiting MAO-B thereby increasing dopaminergic transmition consequently decreasing dopamine metabolites and ultimately preventing the generation of free radicals.