Lung uptake of gold nanoparticles after intraperitoneal administration in vivo: Fluorescence study

摘要

Gold nanoparticles (GNPs) have potential applications in cancer diagnosis and therapy, drug delivery and food industry. Some studies indicate that certain nanoparticles (NPs) may cause adverse effects because of their small size and unique properties. However, little is known about the particle-size and exposure duration of intraperitoneal administration of GNPs in the rat lung tissuein vivo. The aim of the present study was to elucidate the particle size and exposure duration effects of intraperitoneal administration of GNPs on the rat lung tissuein vivousing fluorescence spectroscopy.