Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia

Alexa S. Green; Thiago T. Maciel; Marie-Anne Hospital; Chae Yin; Fetta Mazed; Elizabeth C. Townsend; Sylvain Pilorge; Mireille Lambert; Etienne Paubelle; Arnaud Jacquel; Florence Zylbersztejn; Justine Decroocq; Laury Poulain; Pierre Sujobert; Nathalie Jacque; Kevin Adam; Jason C. C. So; Olivier Kosmider; Patrick Auberger; Olivier Hermine; David M. Weinstock; Catherine Lacombe; Patrick Mayeux; Gary J. Vanasse; Anskar Y. Leung; Ivan C. Moura; Didier Bouscary; Jerome Tamburini

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Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia

机译：Pim激酶调节FLT3-ITD急性髓细胞性白血病对FLT3酪氨酸激酶抑制剂的抗性

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《Science Advances》 |2015年第8期|共页
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Alexa S. Green; Thiago T. Maciel; Marie-Anne Hospital; Chae Yin; Fetta Mazed; Elizabeth C. Townsend; Sylvain Pilorge; Mireille Lambert; Etienne Paubelle; Arnaud Jacquel; Florence Zylbersztejn; Justine Decroocq; Laury Poulain; Pierre Sujobert; Nathalie Jacque; Kevin Adam; Jason C. C. So; Olivier Kosmider; Patrick Auberger; Olivier Hermine; David M. Weinstock; Catherine Lacombe; Patrick Mayeux; Gary J. Vanasse; Anskar Y. Leung; Ivan C. Moura; Didier Bouscary; Jerome Tamburini;
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1. Discovery of N-(4-(6-Acetamidopyrimidin-4-yloxy)phenyl)-2-(2-(trifluoromethyl)phenyl)acetamide (CHMFL-FLT3-335) as a Potent FMS-like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid Leukemia [J] . Liang Xiaofei, Wang Beilei, Chen Cheng, Journal of Medicinal Chemistry . 2019,第2期

机译：发现N-（4-（6-乙酰胺嘧啶-4-基氧基）苯基）-2-（2-（三氟甲基）苯基）乙酰胺（CHMFL-FLT3-335），作为有效的FMS样酪氨酸激酶3内部串联复制（ FLT3-ITD）突变选择性抑制剂用于急性髓性白血病
2. Concurrent Inhibition of Pim and FLT3 Kinases Enhances Apoptosis of FLT3-ITD Acute Myeloid Leukemia Cells through Increased Mcl-1 Proteasomal Degradation [J] . Shivani Kapoor, Karthika Natarajan, Patrick R. Baldwin, Clinical cancer research: an official journal of the American Association for Cancer Research . 2018,第1期

机译：PIM和FLT3激酶的同时抑制通过增加的MCL-1蛋白酶体降解增强FLT3-ITD急性髓性白血病细胞的凋亡
3. Concurrent Inhibition of Pim-1 and FLT3 Kinases in FLT3-ITD Acute Myeloid Leukemia Post-Translationally Downregulates the Anti-Apoptotic Protein Mcl-1 through Downregulation of the Mcl-1 Deubiquitinase USP9X [J] . Baldwin Patrick R., Kapoor Shivani, Natarajan Karthika, Blood: The Journal of the American Society of Hematology . 2016,第22期

机译：同时抑制FLT3-ITD急性髓细胞白血病中Pim-1和FLT3激酶通过下调Mcl-1去泛素酶USP9X来下调抗凋亡蛋白Mcl-1。
4. Novel Inhibitors of T315I Mutant BCR-ABL1 Tyrosine Kinase for Chronic Myeloid Leukemia Disease Through Fragment-Based Drug Design [C] . Satya Anindita, Atika Marnolia, Hersal Hermana Putra, International symposium on bioinformatics research and applications . 2018

机译：T315I突变BCR-ABL1酪氨酸激酶的新型抑制剂通过基于片段的药物设计治疗慢性粒细胞白血病
5. Comparison of FLT3 Inhibitors with the Standard Treatment for FLT3-ITD Mutated Acute Myeloid Leukemia [D] . Argetsinger, Stephanie. 2018

机译：FLT3抑制剂对FLT3-ITD突变急性髓性白血病标准治疗的比较
6. Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia [O] . Alexa S. Green, Thiago T. Maciel, Marie-Anne Hospital, 2015

机译：Pim激酶调节FLT3-ITD急性髓细胞白血病中对FLT3酪氨酸激酶抑制剂的耐药性
7. Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia [O] . Pilorge S, Decroocq J, Zylbersztejn F, 2015

机译：pim激酶调节FLT3-ITD急性髓细胞白血病对FLT3酪氨酸激酶抑制剂的耐药性

Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia

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