Therapeutic potential of d-δ-tocotrienol rich fraction on excisional skin wounds in diabetic rats

摘要

Introduction: Long-standing hyperglycemia in addition to many of its associated complications also hampersnormal wound healing which may be further aggravated in the presence of infection and oxidative stress. Therefore,antioxidant supplementation appears to be strategically relevant for wound healing. This study is designed to explorethe therapeutic potential of d-δ-tocotrienol rich fraction (d-δ-TRF) on skin wound healing in both healthy and diabeticrats. Materials and Methods: Diabetes was induced through single subcutaneous injection of alloxan at the doseof 100 mg/kg at hip region. 24 albino rats were divided into four groups; healthy control, diabetic control, healthytreated and diabetic treated. d-δ-TRF was administered to treated groups (200 mg/kg), orally, daily for 3 weeks. Fullthickness excisional skin wounds were. Wound area was studied by assessing the morphological, histomorphological andhistological features at weekly intervals and biochemical analyses were performed at the end of 3rd week. Results: Thefindings of present study revealed that d-δ-TRF accelerated the skin wound healing by means of early regenerationof both epidermal and dermal components; enhancement of serum protein synthesis, improvement of antioxidantstatus, maintenance of glycemic condition and controlling serum creatinine levels in diabetic rats. Conclusion: It isconcluded that d-δ-TRF has significant therapeutic potency on the healing of skin wounds in both healthy and diabetics.