Synthesis and Antibacterial Activity Study of C-3 ???±, ???2-UnsaturatedKetone Linked Benzofuran Derivatives

摘要

Based on a benzofuran skeleton bearing aryl substituent at its C-3 position through an α, β-unsaturated ketone linker, twenty-one new compounds were chemically synthesized and biologically evaluated for their antibacterial activities against four bacteria, Escherichia coli, Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus, and Bacillus subtilis. Nine of the synthesized benzofuran derivatives exhibited antibacterial activities. Among them, compound 7e showed excellent MIC80 values from 0.78 to 1.56 μg/mL and was comparable to the positive control drugs.