TOSMIC REAGENT: AN EXCELLENT PRECURSOR IN THE SYNTHESIS OF BIOLOGICALLY ACTIVE HETEROCYCLES

摘要

Heterocycles are a major material in the world today, with a wide range of applications which include pharmaceutical, cosmetics, reprography, information storage, plastics, solvents, antioxidants, corrosion inhibition among others. The p-toluenesulfonylmethyl isocyanide (TosMIC) is a rich-rewarding synthetic agent making it valuable template in diverse synthetic applications. Synthetic utilization of TosMIC reagent as a precursor for accessing diverse heterocyclic compounds is worthy of note in the domain of applied research. This study is, therefore, tailored at a review of the progress of the TosMIC reagent as a starting material in the synthesis of heterocycles with well-endowed pharmacological activities.