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Minimally invasive electrochemotherapy procedure for treating nasal duct tumors in dogs using a single needle electrode

机译:使用单针电极的微创电化学疗法治疗狗鼻导管肿瘤

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"Background Nasal cavity tumors are usually diagnosed late, when they already have infiltrated adjacent tissues thus requiring very aggressive treatments with serious side effects. Here we use electrochemotherapy (ECT), a well demonstrated treatment modality for superficial tumors. Materials and methods In the case of deep-seated tumors, the main limitation of ECT is reaching the tumor with an appropriate electric field. To overcome this limitation we introduce the single needle electrode (SiNE), a minimally invasive device that can deliver an appropriate electric field with a simple procedure. Twenty-one canine patients with spontaneous tumors were selected, eleven were treated using the SiNE with ECT, and ten with surgery plus adjuvant chemotherapy as a control group. Results In the SiNE group, 27% achieved a complete response, 64% had a partial response, and 9% had a stable disease. This means that 91% of objective responses were obtained. The mean overall survival was 16.86 months (4–32 months, median 16.5 months), with a survival rate significantly higher (p = 0.0008) when compared with control group. The only side effect observed was the inflammation of the treated nasal passage, which was controlled with corticosteroid therapy for one week. One year after the treatment, 60% of the canine of the SiNE group vs. 10% of the control group remained alive, and after the 32 months follow-up, the survival rate were 30% and 0%, respectively. Conclusions ECT with the SiNE can be safely used in canine to treat nasal tumors with encouraging results."
机译:“背景鼻腔肿瘤通常已经被诊断为晚期,因为它们已经浸润到邻近组织,因此需要非常积极的治疗,并伴有严重的副作用。在这里,我们使用电化学疗法(ECT),这是一种已被证明的浅表肿瘤治疗方法。材料和方法对于深部肿瘤,ECT的主要局限性是要在适当的电场作用下到达肿瘤,为克服此局限性,我们引入了单针电极(SiNE),这是一种微创设备,可以通过简单的过程提供适当的电场选择了21例自发性犬科动物,将11例患者应用siNE和ECT进行治疗,另10例患者接受了手术加辅助化疗作为对照组,结果在SINE组中,有27%的患者获得了完全缓解,有64%的患者获得了完全缓解。部分反应和9%的疾病稳定,这意味着获得了91%的客观反应,平均总生存期为16.86个月(4–32个月,中位数16.5个月),与对照组相比,存活率明显更高(p = 0.0008)。观察到的唯一副作用是经治疗的鼻道发炎,该反应由皮质类固醇激素治疗控制了一周。治疗一年后,SiNE组犬的60%相对于对照组的10%仍然存活,并且在随访32个月后,存活率分别为30%和0%。结论带有SiNE的ECT可以安全地用于犬类鼻腔肿瘤的治疗,效果令人鼓舞。”

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