Inorganic sulfur reduces cell proliferation by inhibiting of ErbB2 and ErbB3 protein and mRNA expression in MDA-MB-231 human breast cancer cells

摘要

>Dietary inorganic sulfur is the minor component in our diet, but some studies suggested that inorganic sulfur is maybe effective to treat cancer related illness. Therefore, this study aims to examine the effects of inorganic sulfur on cell proliferation and gene expression in MDA-MB-231 human breast cancer cells. MDA-MB-231 cells were cultured the absence or presence of various concentrations (12.5, 25, or 50 μmol/L) of inorganic sulfur. Inorganic sulfur significantly decreased proliferation after 72 h of incubation ( P 2 and its active form, pErbB₂, were significantly reduced at inorganic sulfur concentrations of 50 μmol/L and greater than 25 μmol/L, respectively ( P 2 was significantly reduced at an inorganic sulfur concentration of 50 μmol/L ( P 3 and its active form, pErbB₃, and the mRNA expression of ErbB₃ were significantly reduced at inorganic sulfur concentrations greater than 25 μmol/L ( P