Comparison of Oral and Laryngeal Findings of Asthma Patients Using Different Dry Powder Inhaler Devices Containing Steroid and Beta Agonists

摘要

Objective: In this study, we aimed to compare the oral and laryngeal findings of asthma patients using different dry powder inhalers (DPI) containing corticosteroid and long-acting beta-2 agonists. Methods: This study included 109 asthmatics who were divided into 3 groups according to the inhaler device (Seretide Discus [fluticasone 250 mcg, salmeterol 50 mcg], Symbicort Turbuhaler [budesonide 320 mcg, formoterol 9 mcg], and Foradil [formoterol 12 mcg] + Miflonide [budesonide 400 mcg] aerolizer), and compared with 34 healthy controls. Oral and laryngeal regions were examined comprehensively by a rigid telescope. Results: While frequency of oral candidiasis was higher in the group taking budesonide + formoterol by an aerolizer than those of other DPI using groups, frequency of laryngeal candidiasis was more elevated in asthma patients compared to those of healthy controls (p