Hyperbilirubinemia in Term Newborns Needing Phototherapy within 48 Hours after Birth in a Japanese Birth Center

摘要

Background:H yperbilirubinemi a in term newborns need ing phototherapy within 48 hours after birth ,early onset hyperbilirubinemia has not been evaluated in recent Japanese healthy birth center s In thisstudy, we sought to determine the cause of early onset hyperbilirubinemia in a Japanese healthy birthcenter and to evaluate the 1992 Kobe University phototherapy treatment criterion requiring total serumbilirubin (TSB) and unbound bilirubin (UB)Methods:In this retrospective observational study we collected data on newborns diagnosed with earlyonset hyperbilirubinemia between 2009 and 2016 at the Chibune General Hospital . C auses of the diseasewere investigated , as well as w hich index ( TSB or UB was used for treatment decision s.Results:Overall, 76 term newborns were included in the analysis . Twenty seven newborn s (36%) found thecause ABO blood type incompatibility [n=17, 22%], polycythemia [n=8, 11%], and cephalohematoma [n=2,3%])3%]). However, 49 newborns (64%) did not find any causes i.e., idiopathic hyperbilirubinemia) Of these ,27 observed more than 5% weight loss from birth weight. Seventy (92%) newborns had abnormal TSBonly, and 5 (7%) had abnormal TSB and UB values. Only 1 ( newborn with only abnormal UB valuesreceived phototherapy .Conclusions:Altogether, data from this Japanese healthy birth center suggest that many apparently healthynewborns with or without excessive weight loss develop early onset hyperbilirubinemia I n the 1992 KobeUniversity phototherapy treatment criterion TSB , not was the main index used to mak e treatmentdecision s in these patients.