Changing Pattern of Presentation in Monoclonal Gammopathy of Undetermined Significance: A Single-Center Experience With 1400 Patients

摘要

To assess whether the pattern of presentation and the outcome of monoclonal gammopathy of undetermined significance (MGUS) have changed over the last 3 decades, we evaluated 1400 patients, divided into 3 groups: group I (1975-1987), group II (1988-1997), and group III (1998-2007). We observed a significant increase in age (p = 0.001), IgM and biclonal MGUS (p = 0.003), hemoglobin (p 2-microglobulin (p = 0.0001) over the 3 decades. The proportion of patients with M-protein In conclusion, we found that the pattern of presentation of MGUS has changed over time and now includes a higher proportion of patients with more favorable presenting features and probably a better outcome compared to patients presenting in the past. This changing scenario calls for revising the current concepts of the clinical significance of MGUS and the management of patients. Abbreviations: BMPC = bone marrow plasma cells, FLC = free light chains, M = monoclonal, MGUS = monoclonal gammopathy of undetermined significance, SMR = standardized mortality ratio.