Minimal Effects of Age and Exposure to a Noisy Environment on Hearing in Alpha9 Nicotinic Receptor Knockout Mice

摘要

Studies have suggested a role of weakened medial olivocochlear (OC) efferent feedback in accelerated hearing loss and increased susceptibility to noise. The present study investigated the progression of hearing loss with age and exposure to a noisy environment in medial OC-deficient mice. Alpha9 nicotinic acetylcholine receptor knockout (α9ΚΟ) and wild types were screened for hearing loss using auditory brainstem responses. α9ΚΟ mice housed in a quiet environment did not show increased hearing loss compared to wild types in young adulthood and middle age. Challenging the medial OC system by housing in a noisy environment did not increase hearing loss in α9ΚΟ mice compared to wild types. ABR wave 1 amplitudes also did not show differences between α9ΚΟ mice and wild types. These data suggest that deficient medial OC feedback does not result in early onset of hearing loss.