Science Signaling, Perspective – Cancer: Wnt/β-Catenin and MAPK Signaling: Allies and Enemies in Different Battlefields, April 2012

摘要

Research published in Science Signaling [1] represents major advances in cell signaling in many disciplines, including the rapidly expanding areas of signaling networks, systems biology, synthetic biology, computation and modeling of regulatory pathways, and drug discovery. The published research content offers discoveries that substantially refine current understanding of important signaling processes, provide new concepts, and are likely to find application in multiple biological systems. Two papers this year in Science Signaling describe previously unknown links between two signaling pathways that are associated with cancer – melanoma and colon cancer. The Perspective, “Wnt/β-catenin and MAPK Signaling: Allies and Enemies in Different Battlefields,” describes how both studies have implications for the development of combination therapies for skin and colon cancer [2] .