Peruvoside targets apoptosis and autophagy through MAPK Wnt/beta-catenin and PI3K/AKT/mTOR signaling pathways in human cancers

Reddy Dhanasekhar; Kumavath Ranjith; Tan Tuan Zea; Ampasala Dinakara Rao; Kumar Alan Prem

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Peruvoside targets apoptosis and autophagy through MAPK Wnt/beta-catenin and PI3K/AKT/mTOR signaling pathways in human cancers

机译：通过MAPK WNT / BETA-CAT键和PI3K / AKT / MTOR信号传导途径在人类癌症中靶向细胞凋亡和自噬

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摘要

Aim: To investigate the cytotoxic effect of Peruvoside and mechanism of action in human cancers.

机译：目的：探讨危险皂苷和人类癌症作用机制的细胞毒性作用。

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来源
《Life sciences》 |2020年第1期|共17页
作者
Reddy Dhanasekhar; Kumavath Ranjith; Tan Tuan Zea; Ampasala Dinakara Rao; Kumar Alan Prem;
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作者单位

Cent Univ Kerala Sch Biol Sci Dept Genom Sci Tejaswini Hills Periya PO Kasaragod 671320 Kerala;

Cent Univ Kerala Sch Biol Sci Dept Genom Sci Tejaswini Hills Periya PO Kasaragod 671320 Kerala;

Natl Univ Singapore Canc Sci Inst Singapore Singapore Singapore;

Pondicherry Univ Sch Life Sci Ctr Bioinformat Pondicherry 605014 India;

Natl Univ Singapore Canc Sci Inst Singapore Singapore Singapore;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Cardiac glycosides; Peruvoside; Apoptosis; Autophagy; Wnt/beta-catenin pathway; PI3K/AKT/mTOR signaling; Molecular docking;

机译：心脏糖苷;血清糖苷;细胞凋亡;自噬;wnt / beta-catenin途径;pi3k / akt / mtor信号传导;分子对接;

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专利

1. Peruvoside targets apoptosis and autophagy through MAPK Wnt/beta-catenin and PI3K/AKT/mTOR signaling pathways in human cancers [J] . Reddy Dhanasekhar, Kumavath Ranjith, Tan Tuan Zea, Life sciences . 2020,第1期

机译：通过MAPK WNT / BETA-CAT键和PI3K / AKT / MTOR信号传导途径在人类癌症中靶向细胞凋亡和自噬
2. Inhibition of Autophagy Promotes Salinomycin-Induced Apoptosis via Reactive Oxygen Species-Mediated PI3K/AKT/mTOR and ERK/p38 MAPK-Dependent Signaling in Human Prostate Cancer Cells [J] . Kwang-Youn Kim, Kwang-Il Park, Sang-Hun Kim, International Journal of Molecular Sciences . 2017,第5期

机译：自噬的抑制通过人类人体癌细胞中活性氧介导的PI3K / AKT / mTOR和ERK / p38 MAPK依赖性信号传导促进沙利霉素诱导的细胞凋亡。
3. Anti-Tumor Xanthones from Garcinia nujiangensis Suppress Proliferation, and Induce Apoptosis via PARP, PI3K/AKT/mTOR, and MAPK/ERK Signaling Pathways in Human Ovarian Cancers Cells [J] . Zhongyan Tang, Lihua Lu, Zhengxiang Xia Drug Design, Development and Therapy . 2020,第3期

机译：来自Garcinia Nujiangensis的抗肿瘤X吨数抑制了人类卵巢癌细胞中PARP，PI3K / AKT / MTOR和MAPK / ERK信号通路的诱导细胞凋亡
4. Modeling PI3K/PDK1/Akt and MAPK Signaling Pathways Using Continuous Petri Nets [C] . Giulia Russo, Marzio Pennisi, Roberta Boscarino, International conference on intelligent computing . 2017

机译：使用连续Petri网建模PI3K / PDK1 / Akt和MAPK信号通路
5. The multi-targeted receptor tyrosine kinase inhibitor, linifanib (ABT-869), induces apoptosis and inhibits proliferation of leukemia cells through phosphoinositide-3 kinase (PI3K)/AKT-dependent signaling pathways. [D] . Hernandez, Jenny Elizabeth. 2010

机译：多靶点受体酪氨酸激酶抑制剂利尼法尼（ABT-869）通过磷酸肌醇3激酶（PI3K）/ AKT依赖性信号传导途径诱导凋亡并抑制白血病细胞的增殖。
6. BOS-93 a novel bromophenol derivative induces apoptosis and autophagy in human A549 lung cancer cells via PI3K/Akt/mTOR and MAPK signaling pathway [O] . Chuanlong Guo, Lijun Wang, Yue Zhao, -1

机译：BOS-93是一种新型溴酚衍生物可通过PI3K / Akt / mTOR和MAPK信号通路诱导人A549肺癌细胞凋亡和自噬
7. Strophanthidin Attenuates MAPK, PI3K/AKT/mTOR, and Wnt/β-Catenin Signaling Pathways in Human Cancers [O] . Dhanasekhar Reddy, Preetam Ghosh, Ranjith Kumavath 2020

机译：STROPHASTININ衰减人类癌症中的MAPK，PI3K / AKT / MTOR和WNT /β-Catenin信号传导途径

Peruvoside targets apoptosis and autophagy through MAPK Wnt/beta-catenin and PI3K/AKT/mTOR signaling pathways in human cancers

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